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The only literature-reported phase 1 clinical study to date was recently conducted with PF-06882961
Edeas M, Saleh J, Peyssonnaux C
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Additionally, a slight increase in HDL and a decrease in CRP were observed, though these were not statistically significant
While the trial was not designed to formally disentangle weight lossmediated vs weightindependent mechanisms, the magnitude and durability of weight loss likely play a substantial role in risk modification. Clinicians should note that in SELECT, treatment discontinuation due to adverse events was 16% on semaglutide vs 8% on placebo, largely driven by GI events